Diabetic kidney disease
Conditions
Interventions
TCM group:root-securing blood-activating dredging-collateral Traditional Chinese Medicinal formula
Irbesartan goup:Irbesartan
Sponsors
Teaching Hospital of Chengdu University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Male
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. patients must meet the following two diagnostic criteria: (1) Symptoms of diabetes and a casual plasma glucose >= 11.1mmol/l or fasting plasma glucose >=7.0mmol/l or oral glucose tolerance test – two-hour plasma glucose >= 11.1mmol/l and (2) ACR >=300mg/g or 24h UAE >=300mg/24h and glomerular filtration rate (GFR)>=30ml/min.; 2. Diabetes is under control (fasting plasma glucose =30g/L; 6. patients who signed the consent forms.
Exclusion criteria
Exclusion criteria: 1. 24 urinary protein >=3.5g; 2. non-diabetes-induced kidney disease and kidney transplant; 3. intolerant to oral agents or suffered from severe malabsorption; 4. uncontrollable urinary infection and the infections which influence the measurements for urinary protein; 5. pregnancy or lactation; 6. allergic to Traditional Chinese Medicine or ARBs or allergic constitution; 7. severe primary heart, brain, liver and hematopoietic system comorbidities; mental disorders; 8. expected survival time < 1 year; 9. participated in other clinical trials within the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the rate of the change in ACR; | — |
Secondary
| Measure | Time frame |
|---|---|
| the level of ACR;24h urinary protein;eGFR;routine urinalysis;blood glucose;glycated hemoglobin; | — |
Countries
China
Contacts
Public ContactMing Chen
Outcome results
None listed