Pre-pregnancy periodontal Diease
Conditions
Interventions
1:pre-pregancy periodontal disease diagnosis and treatment
2:pre-pregnancy periodontal disease therapy
Sponsors
Fudan University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: at least 20 years old; primipara; pre-pregnancy women who plan to conceive within one year; remaining teeth >= 20; without moderate or severe dental caries; without systemic or reproductive disease; without rheumatoid arthritis; without severe cardiovascular disease; without diabetes; without hyperthyroidism and other systemic diseases; without immunodeficiency diseases; planning to deliver at the participating hospital; diagnosed as having periodontitis after oral examination; willing to be compliant to the follow up during the trial.
Exclusion criteria
Exclusion criteria: less than 20 years old; fewer than 20 teeth; receiving periodontal treatment outside of the study; contraindication to probing in a dental examination and treatment, such as heart disorders; taking antibiotics or drugs that affect the periodontal tissue metabolism;wearing a fixed prosthesis; not pregnant within 12 months after periodontal examination; multiple pregnancy; changed plan for pregnancy (not plan to be pregnant within a year); unwilling or unable to sign the informed consent form; with a disease mentioned in the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PD, CAL and BOP during pregnancy;PD, CAL and BOP during pregnancy;inflammatory cytokines in blood during late pregnancy;the relationship between serum inflammatory factor;the influence of pre-pregnancy periodontal disease; | — |
Secondary
| Measure | Time frame |
|---|---|
| the influence of pre-pregnancy periodontal disease treatment on adverse pregnancy outcomes;levels of inflammatory cytokines in cord blood; | — |
Countries
China
Contacts
Public ContactHong Jiang
Outcome results
None listed