Diabetes
Conditions
Interventions
1:oral administration of the enteric insulin 50IU
2:oral administration of the enteric insulin 100IU
3:oral administration of the enteric insulin 200IU
4:NPH insulin injection 6IU
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
Male
Age
22 Years to 29 Years
Inclusion criteria
Inclusion criteria: 1. subject is a healthy male or female; 2. Age between 18 and 50; 3. BMI 19 to 24kg/m2; 4. No diseases of haemopoietic, renal, hepatic, endocrine, pulmonary, central nervous, cardiovascular, immunological, dermatological, gastrointestinal or any other systems; No obvious abnormalities of the laboratory values; 5. No family history of diabetes or obesity; 6. Nonsmoker status, abstinence from any drug and no beverages (coffee, alcohol or tea et al) intake during study; 7. Willingness to follow the protocol requirement as evidenced by written, informed consent.
Exclusion criteria
Exclusion criteria: 1. With any disease or condition which might compromise the haemopoietic, renal, hepatic, endocrine, pulmonary, central nervous, cardiovascular, immunological, dermatological, gastrointestinal or any other systems; 2. Allergic reaction to any drug, postural hypotension,blood pressure (systolic140 mmHg; diastolic>90 mmHg) heart rate100 bpm; 10. Positive serum hepatitis B surface antigen or hepatitis C antibody; 11. Positive serum HIV-1 or HIV-2 antibody; 12. Consumption of alcohol during study; 13. body weight greater than 5% 0 to 12 months before study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GIR-AUC(0-t);effective duration; | — |
Countries
China
Contacts
Public ContactYerong Yu
Outcome results
None listed