polycystic ovary syndrome
Conditions
Interventions
A:5mg letrozole qd from the 3rd day of menstruation
B:50~150mg clomiphene qd from the 3rd day of menstruation for 5 days
C:500mg metformin tid immediately and 50~150mg clomiphene qd from the 3rd day of menstruation for 5 days.Medication was discontinued when pregnancy was confirmed.
D:500mg metformin tid immediately and 5mg letrozole qd from the 3rd day of menstruation for 5 days.Medication was discontinued when pregnancy was confirmed.
Sponsors
West China Women's and Children's Hospital S.C.U
Eligibility
Sex/Gender
Female
Age
20 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Patients who are diagnosised as PCOS based on the Revised 2003 consensus diagnostic criteria for PCOS; 2. The PCOS patients who want to give birth to a baby; 3. patients With clinical and/or biochemical signs of hyperandrogenism and/or insulin resistance.And those patients need to receive a 3-6 months anti-androgen and/or anti-insulin therapy before included in until above symptons have been relieved.
Exclusion criteria
Exclusion criteria: 1. with other factors affecting pregnance; (1) dysfunction of ovarian ducts:hydrosalpinx,obstruction,stenosis; (2) uterine abnormalities,such as submucous myoma in submucosa or cornua,uterine malformation,intrauterine adhesions,chocolate cyst; (3) abnormal serum PRL or thyroidal disfunction; (4) a positive pulmonary or pelvic TB history; (5) abnormal semen; 2. clinical and/or biochemical signs of hyperandrogenism; 3. BMI>30kg/m2; 4. age>35 years old.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ovulation rate;pregnancy rate;live birth rat; | — |
Secondary
| Measure | Time frame |
|---|---|
| pregnancy lost rate;multipregnancy rate;OHSS morbidity; | — |
Countries
China
Contacts
Public ContactWei Huang
Outcome results
None listed