Acute Heart Failure with hypertension
Conditions
Interventions
Two groups:Urapidil injection titrated to target dose within 6 hours. Treatment lasts for 48 hours.
Sponsors
Department of Cardiology, Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. 18-75 years old, male and female in-patients; 2. Diagnosed as acute heart failure; 3. Killip class >=II, or NYHA Class >=II, acute deficiency phase; 4. Pre-existing hypertension history; 5. Conciousness. Written consent signed.
Exclusion criteria
Exclusion criteria: 1. Systolic blood pressure =3 ULN, Cr>=2 ULN); 5. Known or suspected allergy to investigational product and any ingredient content; 6. Pregnancy, lactation,or women plan to be pregnant; 7. Unappropriate to participant in this study according to investigators' decision; 8. Have taken other investigational products or participanted in other clinical trials within 60 days; 9. Previously enrolled into this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-pro BNP;LVEF; | — |
Secondary
| Measure | Time frame |
|---|---|
| Accumulative mortality rate 7 days and 1 month after treatment;Change in severity of heart failure 48 hours and 7 days after treatment;Change in heart function 48 hours after treatment;Ultrasound cardiography evaluation 48 hours and 7 days after treatment; | — |
Countries
China
Contacts
Public ContactHua Qi
Outcome results
None listed