Mitral valve disease
Conditions
Interventions
A:Mitral valve surgery via right lateral minithoracotomy
B:Mitral valve surgery via conventional sternotomy
Sponsors
Zhongshan hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Patients with isolated mitral valve disease scheduled for mitral valve replacement or mitral valve annuloplasty in the condition that conservative treatment is invalid or indication for surgery is evident; 2) 18 to 75 years old. Male or female; 3) Mitral valve surgery via either right lateral minithoracotomy or conventional sternotomy is suitable; 4) Patients willing to sign the informed consent of this study.
Exclusion criteria
Exclusion criteria: 1) Patients unsuitable for one of the two surgical approaches above-mentioned because of history of chest trauma, infection of the chest area, right chest empyema, surgery for the right lung, etc; 2) Patients with critical condition requiring emergency surgery; 3) Patients with coronary artery disease, congenital heart disease, or aortic valve disease requiring concomitant surgery; 4) Patients with malignant tumor, liver or renal dysfunction, critical condition such as cachexia, or life expectancy less than 2 years; 5) Patients participating in other trials; 6) Patients unwilling to sign the informed consent of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| operation duration (min);CPB time (min);cross-clamp time (min);ICU stay (days);ventilation time (hours);hospital stay (days);blood transfusion;drainage (ml);preoperative TTE;intraoperative TEE;postoperative TTE;CK;CK-MB;cTnT;lung function;S100B;NSE;CRP;SIRS;VAS evaluation;Neuropsychological Tests;complications;death;3 month postoperative TTE;6 month postoperative TTE;12 month postoperative TTE;length of incision;quality of healing of incision;pain of incision;EQ-5D;cost;minimum cost analysis; | — |
Countries
China
Contacts
Public ContactLai Wei
Outcome results
None listed