effect of dexmedetomidine on tourniquet-induced hemodynamic and lung injury in patients undergoing total knee arthroplasty

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-11001714

Enrollment

Unknown

Registered

2011-11-14

Start date

2011-07-18

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

tourniquet-induced hemodynamic and lung injury

Interventions

A:infusion of dex 1ug/kg for 20minutes

B:equal volume of saline for 20 minutes

Eligibility

Sex/Gender

All

Age

60 Years to 75 Years

Inclusion criteria

Inclusion criteria: Age 60-75 years old, ASAI-II, selective total knee arthroplasty, agree to join this study and sign the inform consent

Exclusion criteria

Exclusion criteria: 1. severe vital organ failure; 2. psychological problem; 3. inflation time200mmHg;more than 30% of baseline value; SBP*HR (RPP)>20000, rHR<45/min.

Design outcomes

Primary

Measure	Time frame
heart rate;MAP;PaO2;PA-aO2;OI;????;	—

Secondary

Measure	Time frame
SBP;DBP;CO;SV;SVV;SVR;	—

Countries

China

Contacts

Public ContactLi Yonghua

liyonghua1207@126.com+86 13795439726

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026