Effect of probiotics on the incidence of ventilator associated pneumonia in critically ill patients: a randomized controlled multicenter trial

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-11001713

Enrollment

Unknown

Registered

2011-09-15

Start date

2010-05-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ventilator associated pneumonia

Interventions

probiotic group:probiotics plus standard preventive strategies

control group:standard preventive strategies

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Adult critically illed patients (>=18 years) with an expected need of mechanical ventilation for at least 48h

Exclusion criteria

Exclusion criteria: (1) age 80 years; (2) severe multiple organ failure, APACHE II scores > or = 30; (3) patients who were mechanically ventilated more than 72 hours before admission to ICU; (4) enteral feeding can not start; (5) orally administration of immunodepressants a week before admission or diagnosed with immune supressed diseases, such as maglinant tumor, AIDS, HIV carriers; (6) pregnancy or lactation.

Design outcomes

Primary

Measure	Time frame
incidence of VAP;the day of the oneset of VAP after MV;	—

Secondary

Measure	Time frame
duration of MV;duration of hospital;mortality (at the end of study ICU, hospital);eradication of colonization of oropharynx and stomach;	—

Countries

China

Contacts

Public ContactWang Chunting

wangchunting7051@126.com+86 13370517000

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026