Pain
Conditions
Interventions
perioperative parecoxib group:Patients in perioperative parecoxib group will receive 40mg parecoxib before induction and then 20 mg parecoxib every 12 hours for 60 hours after surgery
postoperative parecoxib group:Patients in postoperative parecoxib group will receive 40mg parecoxib at the end of surgery, and then 20mg parecoxib every 12hours until 60h after surgery.
placebo group:Patients in placebo group will receive normal saline at each time point
Sponsors
Dept. Anesthesiology, Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients between the ages of 18 75 yr; body weight between 40-100kg; ASA physical status I-II; eligible to give informed consent able to cooperate.
Exclusion criteria
Exclusion criteria: Unable to use patient-controlled analgesia (PCA) device due to metal or physical disorder, unable to complete pain questionnaires; hepatic disorder, congestive heart failure, history of myocardial infraction, stroke, pulmonary embolism gastrointestinal ulceration or bleeding , renal insufficiency (serum creatinine>1.5mg/dl), allergic reactions to sulphonamides or NSAIDs, chronic drug or alcohol abuse; taking corticosteroids or NSAIDs within 24 hours before surgery; pregnancy /lactation period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain Intensity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Accumulated opiates dose;Sleep quality;IL-6, IL-1and IL-10 concentration; | — |
Countries
China
Contacts
Public ContactLi Min
Outcome results
None listed