Randomized controlled study of TIPS versus EBL plus propranolol for preventing variceal rebleeding in advanced cirrhotic patients combined with portal vein thrombosis

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-11001577

Enrollment

Unknown

Registered

2011-09-18

Start date

2010-01-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hepatic cirrhosis, esophageal variceal bleeding

Interventions

TIPS group:TIPS

EBL group:EBL+propranolol

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Liver cirrhosis; 2. Endoscopic evidence of variceal bleeding(>=5d); 3. Child-Pugh score: 7–13; 4. Portal vein thrombosis within vessel lumen >25%; 5. Agreed to participate in the trial, and assigned informed consent.

Exclusion criteria

Exclusion criteria: 1. Younger than 18 years or older than 70 years; 2. Pregnant and breeding women; 3. Thrombosis was limited in the intrahepatic portal vein; 4. Portal cavernoma; 5. Isolated gastric varices or ectopic varices; 6. Previous endoscopic treatment, TIPS or shunt surgery; 7. Malignancy or other serious medical illness which may reduce the life expectancy; 8. Uncontrolled infection or sepsis; 9. Severe disorders of other vital organs, such as heart, lung, kidney; 10. Contraindications for endoscopic band ligation, propranolol or TIPS.

Design outcomes

Primary

Measure	Time frame
TIPS dysfunction;	—

Secondary

Measure	Time frame
survival;incidence of complications;hepatic encephalopathy;variceal rebleeding;	—

Countries

China

Contacts

Public ContactXiao Li

simonlixiao@263.net+86 0 13881755965

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026