Ursodesoxycholic acid in biliary complication and early allograft dysfunction after liver transplantation: an multicenter, prospective, open labelled, randomized controlled study (UAILStudy)

Ursodesoxycholic acid in biliary complication and early allograft dysfunction after liver transplantation: an multicenter, prospective, open labelled, randomized controlled study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-11001574

Enrollment

Unknown

Registered

2011-09-21

Start date

2011-10-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic liver diseases and liver cirrhosis

Interventions

UDCA:Take UDCA

B:No UDCA

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Non-heart beating liver transplant recipients; 2. Aged 18-65 years old; 3. The informed consent signed.

Exclusion criteria

Exclusion criteria: 1. Pregnant or breast-feeding women; 2. Severe cardiac or renal dysfunction; 3. Severe endocrinological, hematic or mental diseases; 4. Acute gastric or duodenal ulcer; 5. ABO blood type incompatibility; 6. Cold ischemia time of allograft longer than 15 hours or warm ischemia time longer than 15 mins; 7. Large blood vessels(PV, HV or IVC) invaded by HCC. 8. Follow-up not conducted in the institute of transplantation.

Design outcomes

Primary

Measure	Time frame
Rates of adverse events and severe adverse events;Range of Tbil, GGT and ALP dropping in one month post-transplantation;allograft loss;Rate of rejaction;	—

Secondary

Measure	Time frame
Range of AST and ALT dropping in one month post-transplantation;Early allograft dysfunction;biliary complications, such as bile leakage, bile duct stricture and biliary sludge;death of recipients;	—

Countries

China

Contacts

Public ContactXiaoshun HE

gdtrc@163.com+86 13802510799

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026