severe and extraordinarily severe burn
Conditions
Interventions
A1:Immediate resuscitation + fructose sodium diphosph
A2:Immediate resuscitation + enalaprilat injection
B3:Delayed resuscitation + alprostadil injection
A4:Immediate resuscitation + conventional therapy
B4:Delayed resuscitation + conventional therapy
B2:Delayed resuscitation + enalaprilat injection
A3:Immediate resuscitation + alprostadil injection
B1:Delay resuscitation + alprostadil injection
Sponsors
South West Hospital affiliated to the 3rd Military medical university of People's Liberation Army
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Male or female patients aged 18-65 yrs; 2. Patients with burn injury caused by hot fluid, hot metal or fire. Chemical burn is excluded; 3. Patients with severe and extraordinarily severe burn (TBSA>30% or IIIdegree burn area >20%); 4. Immediate resuscitation group: patients were administrated in hospital within 5h after burn, or received pre-hospital systemic fluid resuscitation; Delayed resuscitation group: patients were administrated in hospital 6h after burn, or received no pre-hospital systemic fluid resuscitation; 5. Serum cTnI >0.15ug/L, or CK-MB>25IU/L.
Exclusion criteria
Exclusion criteria: 1. Patients with history of cardiovascular disease (such as severe congestive heart failure, sick sinus syndrome, II or III AV block, atrial flutter or fibrillation combined with AV bypass, using beta-blocker or digitalis toxication, ventricular tachycardia with QRS>=0.12s); 2. Patients with history of hypertension, hypotension, or wavy blood pressure; 3. Patients with severe disease in heart, kidney, liver, lung and other vital organs, including new myocardial infarction and myocardial damage; 4. Patients with mental disorder and epilepsy; 5. Pregnant or lactating women; 6. Patients were allergic or contradict to the trial drug; 7. Patients with poor adherence; 8. Patients that is eligible for the current study for other reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of infection of wound, bacteria types, drug-resistance and use of antibiotics;Fluid resuscitation parameters: total fluid replacement volume in 48 hrs after burn and the composition;Organ damage parameters: myocardial enzyme, TBA, beta2-MG, DAO; | — |
Secondary
| Measure | Time frame |
|---|---|
| Shock-related parameters: heart rate, blood pressure, CVP, urine volume;Blood parameters: lactic acid, PaO2, HCT, WBC; | — |
Countries
China
Contacts
Public ContactYuesheng Huang
Outcome results
None listed