Bacterial vaginosis
Conditions
Interventions
Group A:Healthy Control
Group B:Bacterial Vaginosis without treatment
Group C:Bacterial Vaginosis treated with metronidazole
Group D:Bacterial Vaginosis treated with Lactobacillus DM8909
Sponsors
Zhejiang University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: The participants who met three or more of the following criteria were clinically diagnosed as BV: homogenous vaginal discharge, >20% clue cells on wet mount, elevated pH (>=4.5) of vaginal discharge, and release of a fishy amine odor upon addition of 10% potassium hydroxide solution to vaginal fluid ("whiff" test) . Then based on the criteria for BV assessment developed by Nugent et al. , participants with the Gram stain score of >=7 were finally confirmed as BV. Participants without these changes were defined as the healthy control group.
Exclusion criteria
Exclusion criteria: 1. <18 years of age; 2. Pregnancy; 3. Diabetes mellitus; 4. The use of antibiotics or vaginal antimicrobials (orally or by topical application in vulvar/vaginal area) in the previous month; 5. Menstruation; 6. Presence of an intrauterine device, vaginal intercourse within the latest 3 days, known active infection due to Chlamydia, yeast, N. gonorrhoeae, or T. vaginalis; 7. Clinically apparent herpes simplex infection, or defined diagnosed HPV, HSV-2, or HIV-1 infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vaginal Bacterial Diversity; | — |
Countries
China
Contacts
Public ContactCharlie Xiang
Outcome results
None listed