hemorrhoids, anal fistulas or anal fissure
Conditions
Interventions
A:Paracetamoland Tramadol Hydrochloride Tablets 400mg, po, qd, three days
B:Placebo, 400mg, po, qd, three days
Sponsors
The sixth Affiliated Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Men or women patients aged 16 years to 60 years with benign anorectal diseases: hemorrhoids (with symptomatic hemorrhoidal diseases and diagnosed with grade III and IV hemorrhoids, the severity of hemorrhoidal disease was classified according to grading system described by Salvati[4], as grade I (hemorrhoids with bleeding but without prolapse), grade II (hemorrhoids with bleeding and protrusion with spontaneous reduction), grade III (hemorrhoids with bleeding and protrusion that require manual reduction), and grade IV (hemorrhoids that are prolapsed and cannot be replaced), fissure in ano (included chronic anal fissure and acute fissure with ineffective expectant treatment and insufferable symptoms: bleeding, itching or pain) or simple anal fistulas(defined as the entire fistula track from internal opening to external opening with identification and obliteration of primary and secondary tracks)[5] , which would need treatment by operation. The operations for the diseases above had common features: wounds with un-sutures and no catheters would be found round the perianal. Especially, as hemorrhoids surgery must combination Milligan-Morgan hemorrhoidectomy, whatever procedure for prolapse and hemorrhoids (PPH), tissue-selecting therapy (TST) or band ligation had been did. The fissure in ano was operated by anal internal sphincter-lysis. As the simple anal fistulas were used fistulotomy but fistulectomy. Routine blood test, liver function test (LFTs), blood urea nitrogen (BUN), blood creatinine (Cr), uric acid (UA), prothrombin time(PT), activated partial thromboplastin time(APTT) and thrombin time(TT) would be claimed normal before surgery.
Exclusion criteria
Exclusion criteria: People had any allergic histories about acetaminophen or tramadol, cranio-cerebral disease, chemical dependency or a long-term administration for pain were excluded. Patients who had previously taken tricyclic antidepressants, non-steroidal anti-inflammatory drug or opioid drug in the latest three months were excluded as well.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Added the amount of pain drugs;Urinary retention;The laboratory test result; | — |
Countries
China
Contacts
Public ContactDong-Lin Ren
Outcome results
None listed