Severe acute pancreatitis
Conditions
Interventions
Normal treatment group:Early retroperitoneal drainage is not performed in this group.
Early drainage group:A percutaneous drain (at least 12 French) is placed in the (peri-)pancreatic collection with the assistance of ultrasound, within 24 hours after randomization. The preferred route
Sponsors
Xijing Hospital of The Fourth Military Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. age equal to or above 18 years, equal or less than 75; 2. Gut Dysfunction score>9; 3. Balthazar CT score=Grade D or Grade E; 4. possibility of placing a catheter into the retroperitoneal space percutaneously; 5. written informed consent.
Exclusion criteria
Exclusion criteria: 1. previous drainage or surgical necrosectomy for (suspected); infected pancreatic necrosis, including procedures performed in referring hospitals. ERCP with or without papillotomy is allowed; 2. previous exploratory laparotomy for acute abdomen and diagnosis of pancreatitis during laparotomy; 3. history of acute or chronic pancreatitis; 4. bleeding, or perforation of a visceral organ as indication for intervention; 5. malignancy; 6. pregnancy; 7. mental illness; 8. identification of patients > 7days after onset of symptoms; 9 bacteremia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mortality;total costs; | — |
Secondary
| Measure | Time frame |
|---|---|
| local complications;Infection rate;Recovery time of gut dysfunction;organ failure;beginning time of enteral nutrition;total number of interventions;necrosectomy;major complications;long-term complications;total hospital stay; | — |
Countries
China
Contacts
Public ContactQin-chuan Zhao
Outcome results
None listed