post-operative cognitive dysfunction
Conditions
Interventions
control group:Patients received continuous intravenous administration of normal saline with the same speed as the intervention group from the beginning of operation to 12 hours after operation.
intervention group:Lidocaine was slowly injected intravenously with the dose of 1.5mg/kg and then infused continuously with the rate of 2mg/min after general anesthesia and central venous catheterizat
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) selective coronary artery bypass graft surgery (2) aged 18 to 90 years old (3) more than 5 years of schooling (4) residents in Bejing or the districts around
Exclusion criteria
Exclusion criteria: (1) patients who refuse to participate in this study (2) patients who can not finish the neurological and psychological tests (3) patients who will receive procedures of big vessels and other non-cardiac operations together with cardiac surgery (4) patients with past chest operation history (5) patients with past psychological disorder history (6) patients with neurological sequelae of cerebral vascular diseases (7) patients with cardiac dysfunction>? and/or angina pectoris>? and/or LVEF2.0mg/dl or 177umol/L) (10) patients with active liver diseases (11) patients with a suspicious allergic history to lidocaine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative cognitive dysfunction (POCD) at 8 weeks after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in intensive care unit (ICU) after surgery;Length of stay in hospital after surgery;Incidences of POCD;Incidences of stroke at 1 week, 3 months and 5 years after surgery;Mortality rates;Quality of life; | — |
Countries
China
Contacts
Public ContactWang Dong-xin
Outcome results
None listed