severe sepsis and septic shock
Conditions
Interventions
control group:central venous pressure guides fluid therapy
research group:passive leg raising guides fluid therapy
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. age > 18 yrs; 2. severe sepsis and septic shock was diagnosed according to the criteria proposed by SCCM/ESICM/ACCP/ATS in 2001; 3. presence of at least one clinical sign of inadequate tissue perfusion defined as (1) systolic blood pressure below 90 mmHg (or a decrease > 40 mmHg in previously hypertensive patients ) or the need for vasopressive drugs; (2) urine output =2 hours; (3) heart rate > 100 beats/min; (4) presence of skin mottling; (5) persistent hyperlactacidemia.
Exclusion criteria
Exclusion criteria: 1. increase in intracerebral pressure; 2. PaO2/FiO2 < 100 mmHg; 3. left ventricular ejection fraction < 40%; 4. pulmonary hypertension; 5. increase in intra-abdominal pressure; 6. obvious hypovolemia; 7. elastic compression stocking or deep venous thrombosis; 8. aortic or mitral valve disease; 9. ascending aortic aneurysm.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| in-ICU mortality; mortality at 28 days; the length of stay in hospital; PaO2/FiO2 after early goal-d; | — |
Secondary
| Measure | Time frame |
|---|---|
| in-ICU mortality; | — |
Countries
China
Contacts
Public ContactLei Huang
Outcome results
None listed