Clinical Study for Prevention and Trentment of Enterogenic Infection with Reconstruction of Intestinal Mucosal Barrier in Severely Burned Patients

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-11001389

Enrollment

Unknown

Registered

2011-06-01

Start date

2011-07-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

severe burn

Interventions

Group A:Glutamine + probiotic therapy

Group B:Glutamine + prebiotic therapy

Group C:Glutamine + probiotic + prebiotic therapy

Group D:Conventional therapy

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. TBSA>30%, deep second degree burn/third degree burn; 2. Aged 18 to 68 years old, male or female; 3. Patients admitted within 24h after injury.

Exclusion criteria

Exclusion criteria: 1. Head injury required special treatment; 2. Thoracoabdominal injury required surgical treatment; 3. Multiple fracture; 4. A history of cancer; 5. Diabetes; 6. History of cardiovascular disease ; 7. Acute and chronic liver and kidney dysfunction before injury; 8. acute and chronic intestinal diseases before injury; 9. Known to have human immunodeficiency virus infection or other deadly diseases.

Design outcomes

Primary

Measure	Time frame
plasma DAO;Plasma endotoxin;C-reactive protein, prealbumin, transferrin;Faecal bacteria ball / rod ratio;Urine Lactulose/Mannitol ratio;Culture and sensitivity of bacteria from blood and wound;	—

Secondary

Measure	Time frame
Mortality;Faecal sIgA;Plasma procalcitonin;	—

Countries

China

Contacts

Public ContactYizhi Peng

yizhipen@sina.com+86 23 68754175

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026