primary liver cancer.
Conditions
Interventions
Mild pain group:External application of Shuangbai San or placebo (Treating burst pain with tramadol injection)
Moderate-severe pain group:External application of Shuangbai San or placebo + orally taking morphine sulfate (treating burst pain with morphine injection)
Sponsors
Guangzhou University of TCM
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Clinical and pathological confirmed primary liver cancer Diagnosis standard is according to the cancer fascicule of clinical diagnosing and treating guideline (2005); 2. Patients with pain in upper abdomen or liver area; 3. Predicted survival>2 months; 4. Karnosfskye score>=20; 5. Aged 18-85 yrs; 6. No history of drug abuse or allergy; 7. Voluntarily signed the informed consent and having good adherence.
Exclusion criteria
Exclusion criteria: 1. Patients with severe heart, brain, kidney, hematology or psychological disease; 2. Severe pain due to the primary liver cancer combined with liver rupture and bleeding; 3. Severe complications such as refractory ascites, biliary fistula, Intraperitoneal infection, GI bleeding, hepatic failure and intraperitoneal bleeding, etc.; 4. Pregnant or lactating women; 5. Allergic to multiple medicine or trial drug; 6. Experienced operation, interventional therapy, radiofrequency ablation or neural blocking therapy 1 week before the trial; 7. Patients who are considered not suitable for the trial by the researcher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of life, simple pain questionnair, digital pain evaluation; | — |
Secondary
| Measure | Time frame |
|---|---|
| ß-endorphin; | — |
Countries
China
Contacts
Public ContactXiaowei Ye
Outcome results
None listed