mitral valve disease and aortic valve disease
Conditions
Interventions
Group A:receiving sevoflurane (1 minimal alveolar concentration MAC) during the entire procedure and pulmonary static inflation with hypothermia gas(10 degree C).
Group B:receiving sevoflurane (1 MAC) during entire procedure and pulmonary static inflation with room temperature gas(24 degree C)
Group C:receiving propofol (4-6mg/kg?h) during the entire procedure and pulmonary static inflation with hypothermia gas(10 degree C).
Group D:receiving propofol (4-6mg/kg?h) during entire procedure and pulmonary static inflation with room temperature gas(24 degree C).
Sponsors
The 2nd affliated hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male and female aged 40 to 70 years old; 2. ASA grade stage 3 to 4; 3. Able and willing to provide signed signed informed consent; 4. Have elective cardiac valve replacement.
Exclusion criteria
Exclusion criteria: 1. Left ventricular ejection fraction (EF) <40% in preoperative period; 2. With hypotension that needs inotropic drugs or mechine to sustain normal level in preoperative period; 3. With coronary heart disease, congestive heart failure, stage 3 to 4 of liver and kidney dysfunction, chronic obstructive pulmonary disease or other respiratory dysfunction, disease of central nerves system, abnormality of haemostasis; 5. Severe pulmonary hypertension, left-to-right shunts heart diseases; 6. Had been treated with percutaneous balloon, mitral valvotomy or other cardiovascular surgeries; 7. Treated with hypoglycemic agents, theophylline agents, immune potentiator or suppressive agents and non-steroidal anti-inflammatory drugs (NSAIDs) before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| oxygenation index;Extravascular Lung Water Index;Respiratoryindex;proinflammatory factors;Pulmonary Vascular Permeability Index;lung compliance; | — |
Secondary
| Measure | Time frame |
|---|---|
| neutrophile cell count;socre of chest X-ray;Cardiac output index; | — |
Countries
China
Contacts
Public ContactWenzhi LI
Outcome results
None listed