epithelial ovarian cancer
Conditions
Interventions
Control:Day 1: Paclitaxel 135 mg/m2
Day 2: Carboplati AUC=5
repeat every 3 wks for 6 cycles.
Treatment:Day 1: Paclitaxel 135 mg/m2
Day 2: Aoxianda 80mg/m2
Sponsors
1st people hospital of Shanghai
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. epithelial ovarian cancer (II stage at least) confirmed by pathology or cytology; 2. Patients who need chemotherapy after successful cytoreductive surgery (residual tumor diameter60; 4. expectant survival >6 month; 5. Aged 18-70 yrs; 6. hemopoietic function of bone marrow is normal: WBC>=4*10^9/L, N>=2.0*10^9, Hb>90g/L, PLT >=100*10^9/L; 7. AST and/or ALT is lower than 2.5 times of UL, serum total bilirubin <1.5 times of UL; 9. Normal heart, lung, liver and kidney function10 No intracranial and bone metastases11 Patients who have good adherence.
Exclusion criteria
Exclusion criteria: 1. Patients who participated in other trial or used other medicine in last 4 wks. 2. Patients with severe uncontrolled disease or acute infection. 3. Patients with another primary malignant neoplasm. 4. Pregnant or lactating women 5. Patients with peripheral neuropathy (>=2 stage)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival;CA125;Quality of life;Progress-free surviva; | — |
Countries
China
Contacts
Public ContactYouji Feng
Outcome results
None listed