pneumonia
Conditions
Interventions
Group A:Vancomycin Hydrochloride (Vanocin) 1g q12h intermittent infusion or a total daily dosage adjusted according to the baseline serum creatinine concentration twice daily
Group B:Vancomycin Hydrochloride (Vanocin) loading dose of 0.5g infused in 1h, followed by a 24h continuous infusion of total daily dosage which was adjusted according to the baseline serum creatinine
Sponsors
Third Hospital of Changsha
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Male and female aged 18 years old and over; 2. Able and willing to provide signed informed consent; 3. MRS pneumonia established by microbiological and clinical diagnosis.
Exclusion criteria
Exclusion criteria: 1. Received vancomycin therapy within 3 days before current treatment; 2. Previous allergy to glycopeptides or aminoglycosides; 3. Cute renal failure or received peritoneal dialysis or hemodialysis; 4. Neutrophilic granulocyte<2.0*10^9/L; 5. Died within 3 days of administration or died of other non-MRS-infection during the treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| death;body temperature, leukocytes and Clinical symptoms;clearance of MRS from lower respiratory tract spen; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lung imaging examinations; | — |
Countries
China
Contacts
Public ContactHuande Li
Outcome results
None listed