adult acute kidney imparement after cardiopulmonarybypass
Conditions
Interventions
control group:the patients of control group will be administrated saline the same way as the dexmedetomidine
dexmedetomidine group:Patients of dexmedetomidine group will be administrated initial dose of dexmedetomidine (0.5ug /kg) pump over 10 min 30 minutes before induction of anesthesia, subsequently recei
Sponsors
Nanjing First Hospital affiliated to Nanjing Medical University
Eligibility
Sex/Gender
All
Age
19 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. patients whose ASA are within I-III; 2. adult subjects scheduled to undergo cardiac surgery under cardiopulmonary bypass; 3. Patients who signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant women; 2. patients who received long-term dialysis; 3. patients who received acute dialysis before surgery; 4. patients who received organ transplantation within the last year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urinary KIM-1;serum NGAL, urinary NGAL;urinary L-FABP;serum Cys C; | — |
Secondary
| Measure | Time frame |
|---|---|
| serum albumin, serum BUN, serum Cr, Glu, serum beta 2 microprotein, serum uric acid; | — |
Countries
China
Contacts
Public ContactHongguang Bao
Outcome results
None listed