Osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with unilateral or bilateral OA of the knee according to the criteria of the American College of Rheumatology for more than 3 months; 2. After discontinuation of usual medications for 7 days, the visual analog scale (VAS) score assessing pain during the most painful knee movement must be between 40-70; 3. Participants must be able to walk and give both verbal and written information regarding the study.
Exclusion criteria
Exclusion criteria: 1. Underlying inflammatory arthropathy, expectation of surgery in the near future, recent injury in the area affected by OA of the knee, intra-articular corticosteroid injections within the last 3 months, history of peptic ulceration and upper GI hemorrhage, coagulopathies, uncontrolled hypertension, congestive heart failure, diabetes, hyperkalemia, pregnancy, lactation and malignant tumors; 2. In patients randomized to recieve oral NSAIDs, the exclusion criteria also include hypersensitivity to NSAIDs, abnormal liver or kidney function tests, and major abnormal finding on complete blood count.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analog scale (VAS) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lequesne's functional index; | — |