diabetic nephropathy
Conditions
Interventions
A:telmisartan + placebo for probucol
B:telmisartan + probucol
Sponsors
General Hospital of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. aged from 18 to 70 years old, male or female; 2. hypertension (blood pressure =0.5 and <3.0g; 4. serum creatinine <265umol/L (3mg/dl); 5. glycated hemoglobin <=8%; 6. Voluntarily participate in the study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. a previous intolerance or allergy history of probucol or telmisartan; 2. concomitant non-diabetic nephropathy; 3. blood pressure 5.5mmol/L or <3.5mmol/L; 5. breast-feeding, pregnancy or planned pregnancy during the study period; 6. unilateral or bilateral renal artery stenosis; 7. new myocardial infarction within one month; 8. serious ventricular arrhythmias; 9. cardiac or unexplained syncope; 10. Q-T interval prolongation or Q-T interval is prolonged with drugs; 11. use of tricyclic antidepressants or phenothiazine drugs; 12. cardiac surgery or interventional procedures within one year; 13. obstructive biliary disease; 14. severe liver dysfunction; 15. multiple organ failure or cancer; 16. psychiatric disorders or poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urine protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| cardiovascular system function;renal function; | — |
Countries
China
Contacts
Public ContactXiangmei CHEN
Outcome results
None listed