Idiopathic membranous nephropathy
Conditions
Interventions
CTX:CTX 0.5-0.75g/m2, max 1g, pred 1mg/kg/d 65y, pred 0.5mg/kg/d
for 12 months
FK 506:FK506 0.1mg/kg/d, for 12months, pred 0.5mg/kg/d
Sponsors
Shanghai Jiaotong University Affiliated Ruijin Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Idiopathic membranous nephropathy patients proven by biopsy within 24 weeks; (2) 24-hour urinary protein excretion at admission no less than 5g or serum albumin less than 25g/L; (3) The patient had renal insufficiency defined as CKD 2~3 stage with moderate proteinuria or severe NS with pleural effusion, ascites, renal venous thrombosis; (4) NS patients without severe edma, follow-up 3 months,24-hour urinary protein excretion more than 5g or serum albumin less than 25g/L; (5) Written informed consent.
Exclusion criteria
Exclusion criteria: (1) Secondary membranous nephropathy,including Lupus, Malignancy, Hepatitis B virus infection,drug induced; (2) Patients used immunosuppressive therapy including FK506, MMF, CTX, CsA within 3 months; (3) Known hypersensitivity to KF506, prednisone or CTX; (4) Severe infection, heart failure and central nervous system disorders; (5) Severe Immunodeficiency, active gastrointestinal disease, or myelodysplastic; (6) Females who are pregnant, breast feeding, or at risk of pregnancy; (7) Positive serum parameters for hepatitis B; (8) Patients with poor compliance by medical staff; (9) Post renal transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour urinary protein excretion;Serum albumin;serum creatine; | — |
Countries
China
Contacts
Public ContactNan CHEN
Outcome results
None listed