Gastrointestinal disease
Conditions
Interventions
1:Control group: (weight in kilograms * 1 / 8) normal saline intravenously in 15 minutes +10 mi / h normal saline until extubation
2:Experimental group 1: intravenous infusion of 0.5ug/kg (weight) dexmedetomidine completed 15 minutes of scheduled +0.25 ug / kg / h constant intravenous infusion of dexmedetomidine given to extubati
3:Group 2: intravenous infusion of 0.5ug/kg (weight) dexmedetomidine completed 15 minutes of scheduled +0.5 ug / kg / h constant intravenous infusion of dexmedetomidine given to extubation
Sponsors
Department of Anesthesiology, First Affiliated Hospital of Sun Yat-sen Univercity
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 64 years, gastrointestinal disease, undergoing elective gastrointestinal surgery patients; 2. General is still good, ASA grade 1 or 2 level; 3. Understood and signed informed consent clinical trials.
Exclusion criteria
Exclusion criteria: 1. preoperative severe dysfunction of heart, lung, blood vessels, liver and kidney; 2. a narcotic drug allergy history or family history of narcotic-related adverse events; 3. body mass index (BMI)> = 30kg/m2; 4. 1 week before surgery with respiratory infection, fever history; 5. with serious mental illness or cerebral palsy or deaf patients; 6. used antidepressants or antiepileptic drugs; preoperative 3 months; 7. pregnant and lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extubation time;various total dose of propofol, fentanyl, remifentanil, dexmedetomidine intraoperatively;Value of propofol TCI;Recovery time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Narcotrend value; | — |
Countries
China
Contacts
Public ContactLiangcan XIAO
Outcome results
None listed