type 2 diabetes with carotid artery atherosclerosis
Conditions
Interventions
treated group A:HBA1c>7%+other risk factors intervention+detection of SPECT
control group a:HBA1c>7%+other risk factors intervention
treated group B:HBA1c7%+other risk factors intervention
treated group D:HBA1c>7%+other risk factors intervention
Sponsors
Southwest Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male and female aged 45 to 80 years old; 2. Diagnosis of type 2 diabetes mellitus according to the WHO(1999) criteria and stable diabetes therapy for at 3 months; 3. CIMT >=1 mm or exist plaque(diameter>=1mm); 4. Ability to perform all tasks related to glycemic control and risk-factor management and accepted detection of myocardial function and informed written consent.
Exclusion criteria
Exclusion criteria: 1. Hepatic and renal disease (serum creatinine >=1.2 times the upper limit of normal,alanine aminotransferase >=2 times the upper limit of normal); 2. Existed ketosis or etoacidosis or hyperosmolar nonketotic diabetic coma or gross stress reaction in the past half a year; 3. Pregnant or lactating women; 4. History of mental aberration; 5. Hemorrhagic tendency; 6. Noncardiac illness expected to limit survival; 7. Current alcohol abuse; 8. Enrolled in a competing randomized trial or clinical study in the past 4weeks; 9. Geographically inaccessible or unable to return for follow-up; 10. Unable to understand or cooperate with protocol requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cardiovascular end point events; | — |
Secondary
| Measure | Time frame |
|---|---|
| biochemical indices of lipid;coronary arteriongraphy;biochemical indices of glucose;biochemical indices of hypertension; | — |
Countries
China
Contacts
Public ContactBing Chen
Outcome results
None listed