Gastric Cancer
Conditions
Interventions
contrul group:FP regiem chemtherapy
experiment group:Celecoxib+FP regiem chemtherapy
Sponsors
The First Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Advanced gastric cancer confirmed by pathology, losing chance of radical surgery, or recurrence after surgery, no chemotherapy previously; 2. ECOG PS 0-2, Expected survival>12 weeks; 3. With normal function of vital organs: blood routine test: ANC>=1.5*10^9/l, PLT>=100*10^9/l, HB>=9g/l, liver function: TBIL <1.5normal limit, ALT/AST<2.5 normal limit for no liver metastasis, <5 normal limit for liver metastasis, renal function: Cr<1.25 normal limit, and normal ECG; 4. Aged from 18 to 65 years old; 5. Having mesurable lesions for RECIST criteria; 6. Understand contents of the study and sign informed consent forms.
Exclusion criteria
Exclusion criteria: 1. With severe allergic history, uncontrolled diabetes, hypertension and digestive ulcer; 2. With symptomatic brain metastasis; 3. With uncontrolled psychopathy; 4. Pregnant or breast-feeding women; 5. Using NSAID within 30 days of the study; 6. With other situation unsuitable for enrollment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Quality of Life;Response rate;Disease control rate; | — |
Countries
China
Contacts
Public ContactYongning ZHOU
Outcome results
None listed