Childhood obstructive sleep apnoea
Conditions
Interventions
Two groups:Adenotonsillectomy versus close monitoring and direct contact of the research team if necessary
Sponsors
Department of Paediatrics, Chinese University, Hong Kong
Eligibility
Sex/Gender
All
Age
6 Years to 11 Years
Inclusion criteria
Inclusion criteria: (i) Hong Kong Chinese prepubertal children aged between 6-11 years; (ii) Mild OSA confirmed by nocturnal PSG (obstructive apnoea hypopnoea index (OAHI) between 1 and 5) and parental report of habitual snoring (at least 3 nights per week); (iii) Tonsil size grading >=1; (iv) Written informed consent obtained from parents.
Exclusion criteria
Exclusion criteria: (i) Previous upper airway surgery. (ii) Diagnosed to have attention deficit hyperactivity disorder (ADHD) or other psychiatric behavioural problems. (iii) Craniofacial anomalies. (iv) Severe health problems that could be exacerbated by delayed treatment of OSA. (v) SpO2 nadir =95th percentile (corresponding to a z score of 1.645) of the local reference.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Omission T score of Conners’ continuous performance test (CPT) at 6 months.; | — |
Secondary
| Measure | Time frame |
|---|---|
| (i) Polysomnographic changes.;(ii) 24-hr blood pressure.;(iii) Attention, assessed by Test of Everyday Attention for Children (TEA-Ch).;(iv) Commission and reaction time T scores of CPT.;(v) Working memory.;(vi) Executive function;(vii) Non-verbal reasoning;(viii) Quality of life;(ix) Child Behavior Checklist (CBCL).;(x) Teacher’s Report Form (TRF).;(xi) Symptoms of attention deficiency / hyperactivity disorder (ADHD) assessed by ADHD rating scale-IV parents version (investigator administered) [3];(xii) Daytime sleepiness assessed by a Chinese version of the Pediatric Daytime Sleepiness Scale (PDSS). [4];(xiii) Fasting insulin and glucose, serum lipid profile and serum inflammatory marker; high sensitive CRP (hs-CRP).; | — |
Countries
China
Contacts
Public ContactMr. Au Chun Ting
Department of Paediatrics, Falculty of Medicine, The Chinese University of Hong Kong
Outcome results
None listed