recurrent aphthous ulceration
Conditions
Interventions
experimental group:Placebo 3 times a day, for 5 days
control group:dexamethasone ointment 3 times a day, for 5 days
Sponsors
West China College of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. aged 18 to 60 years old; 2. more than six months of the history of RAU and with expectation that the ulcers normally take more than 5 days to resolve without treatment; 3. presenting with 1-3 aphthous ulcers (<48 hours' duration) with a size <10 mm in diameter; 4. ulcers must be in locations easily accessible for evaluation and treatment; 5. negative reaction to pregnancy test in women.
Exclusion criteria
Exclusion criteria: 1. history of allergies to dexamethasone or a known history of serious drug hypersensitivities; 2. major aphthous ulcer, herpetiform ulcer, Behcet's disease, premenarcheal ulcer or with other severe oral mucosal diseases; 3. using any agents for ulcers during the previous 48 hours; 4. orthodontic braces or retainer that might come into contact with the ulcer; 5. those with severe systemic diseases or abnormal hepatic or renal function test; 6. pregnancy or intention of pregnancy or lactation or use of contraceptives of steroid hormone recently; 7. history of psychiatric disorders; 8. being addicted to smoking and alcohol; 9. attendance of any other clinical trials prior to 3 months of entering this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| duration and healing ratio of the ulcers; | — |
Secondary
| Measure | Time frame |
|---|---|
| ulcer size, pain index; | — |
Countries
China
Contacts
Public ContactHongmei Zhou
Outcome results
None listed