lumbar intervertebral disc protrusion
Conditions
Interventions
1:0.9%Sodium Chloride
2:0.5mg/ml Mitomycin C
Sponsors
The Affiliated Hospital With Nanjing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All patients presented with painful sciatica that was refractory to conservative treatment which had included bed rest, non-steroidal anti-inflammatory medication, epidural blocks and selective nerve root blocks and compression of the involved nerve root was confirmed by imaging studies.
Exclusion criteria
Exclusion criteria: 1. Patients were excluded if they had previously undergone spinal surgery, if they had been treated with epidural steroid drugs within 4 weeks of the proposed surgery, if they had been treated with oral steroid agents within 10 days of the surgery, or if they had received aspirin or other nonsteroidal antiinflammatory drugs within the 7 days preceding the surgery; 2. Patients who had undergone myelography or lumbar puncture within 24 hours of the surgery also wereexcluded. All patients were evaluated before the surgery by an internal medicine specialist who performed physical and cardiological examinations, chest radiographs, and standard laboratory analyses including complete blood count, chemistry panel, hepatic and renal tests, and urinalysis; 3. Patients with systemic illness, allergy, local/general infection,or slight anemia all were excluded from the study. To determine if there were any adverse effects of the drug, these same tests were done during the 1st week and the 1st month after surgery; no abnormality was found. Involvement in a workers’ compensation claim was another criterion for exclusion; 4. Patients were excluded intraoperatively if dural injury occurred.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Image Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Physical Symptoms and Radiculopathy Score;Functional Disability and Activity-Related Pain;Leg Pain Severity Score; | — |
Countries
China
Contacts
Public ContactXiaojian Cao
Outcome results
None listed