Rheumatoid Arthritis
Conditions
Interventions
Group A:observation group: Leflunomide Tablets, from the first day to the third day, 50mg, qd, po, then 20mg, qd, po. Ligustrazine Powder-Needle, 0.12g, solubling in 5% GS/NS 100ml, qd, iv, in 30 to 6
Group B:control group: Leflunomide Tablets, from the first day to the third day, 50mg, qd, po, then 20mg, qd, po.
Sponsors
Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Be diagnosed with RA as defined by the 1987 America College of Rheumatology (ACR) criteria, and the disease progression is in the I, II, or III phase, in active phase; 2. Sign the informed consent by patient or guardian; 3. Platelet count>=100*10^9/L.
Exclusion criteria
Exclusion criteria: 1. To combine with severe diseases in cardiovascular, lung, liver, renal, hematopoietic systems, or have to apply glucocorticoids for hyperpyrexia, interstitial pneumonia, renal amyloidosis, constrictive pericardium, central nervous system vasculitis; 2. To take the following drugs for a long-term till 1 month before participating in this study: glucocorticoids, chloroquine, sulfasalazine, cyclophosphamide, penicillamine, gold preparations, anticancer agent, and Chinese medicine which has the similar efficacy for RA; 3. Being involved in other clinical trials at present or 1 month before participating in this study; 4. Researchers in this study; 5. Inaptitude for the clinical protocols, for example, being allergic to sulfanilamide; 6. Combine with gastrointestinal tract diseases in active phase, to have esophagus or enteron ulcers within 30 days before participating in this study (don't exclude patients with alimentary tract hemorrhage history long before); 7. Platelet count<100*10^9/L or with t hemorrhagic tendency, or thrombocytopenia history long before; h. women during pregnancy or lactation, or planning to get pregnant; 8. Men who want to generate; 9. Mental patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rest pain, pressing pain on joints, arthrocele, early morning stiffness, average grip of both hands; | — |
Secondary
| Measure | Time frame |
|---|---|
| Laboratory examinations: ESR, RF, CRP, IgA, IgG, IgM, hemorheology, X-ray, Pattern information of Chinese Medicine; | — |
Countries
China
Contacts
Public ContactAiping Lu
Outcome results
None listed