Continous epidural chloroprocaine for the management of postoperative pain in patients undergoing lower extremity rthopaedic surgery

The efficacy and safety of five concentrations of chloroprocaine combained with 0.00004% sufentanyl administered as patient-controlled epidural analgesia after lower extremity orthopaedic surgery: a m

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-10000987

Enrollment

Unknown

Registered

2010-08-20

Start date

2008-10-01

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative pain

Interventions

A:continous epidual 0.6% chloroprocaine

B:continous epidual 0.8% chloroprocaine

C:continous epidual 1.0% chloroprocaine

D:continous epidual 1.2% chloroprocaine

E:continous epidual 1.4% chloroprocaine

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Male and femal aged 18 to 65 years old; 2. ASA 1-2; 3. Body weight 40-90 kg; 4. IBM 18028; 5. Selective lower extremity rthopaedic surgery; 6. Able and willing to provide signed informed consent.

Exclusion criteria

Exclusion criteria: 1. History of cardiavascular disease, hypertension, hypotension; 2. Contraindication to epidual anesthesia; 3. Neurologic problems involving the lower extremities; 4. Allergies to any drugs that are to be administered during the study; 5. Alcohol or drug dependency.

Design outcomes

Primary

Measure	Time frame
Vomiting;Blood loss;Nausea;Pruritus;Pruritus;Heart rate;Duration of surgery;Modified Bromage score;Hidrosis;	—

Secondary

Measure	Time frame
Blood pressure;VAS score;	—

Countries

China

Contacts

Public ContactChaoran Wu

chaoranwu@yahoo.com.cn+86 18980601146

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026