osteoarthritis
Conditions
Interventions
1:receive parecoxib 40mg IV at the completion of surgery and 40mg iv bid for 3 days after surgery
2:receive normal saline 2ml
Sponsors
Shanghai Changzheng Hospital
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: With Institutional Ethic Committee approval and patient's signature on consent, 100 patients will be enrolled who have an ASA physical status of I to II, between 55–75 years of age, scheduled undergoing routine total primary arthroplasty for unilateral knee with a standardized regimen of general anaesthesia.
Exclusion criteria
Exclusion criteria: Patients will be excluded who will undergo a revision to a previous TKA, emergency TKA, or TKA as a result of a trauma. Patients with a history of coagulopathy or of a thromboembolic event, serum creatinine >100 umol/L in women and >115 umol/L in men, acute infection, malignant disease, unstable angina, myocardial or cerebral infarction within 1 year prior to operation, and allergy to NSAIDs or sulphonamides. Those with inflammatory bowel disease, a chronic or acute hepatic disorder will be excluded too.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| Range of motion (ROM);The PGE2 and IL-6 level in drainage;VAS Pain score; | — |
Countries
China
Contacts
Public ContactYunli Zhu
Outcome results
None listed