Post-stroke patients with chronic non-fluent aphasia
Conditions
Interventions
Group A:Oral administration of donepezil, the first month
Group B:Placebo 10mg / day.
Sponsors
Nanfang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18 to 80 years; 2. The course of disease is more than three month; 3. Cortical-subcortical or subcortical lesions caused by infarction or hemorrhage; 4. The patients give the informed consent after detailed explanation of this study; 5. Vision and hearing capabilities that allowed compliance with testing procedures; 6. Medically stable condition.
Exclusion criteria
Exclusion criteria: 1. Dementia, psychiatric disorders and conscious disturbance; 2. Dysarthria; 3. Acute or serious pulmonary, gastrointestinal, renal, hepatic, endocrine, cardiovascular disease or cancer; 4. Epilepsy have not been controled; 5. Use of cholinesterase inhibitors and other N–methyl-D-aspartate antagonists within four weeks; 6. Pregnancy, lactation or intended pregnancy; 7. Have hydrochloride allergy history of donepezil.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Aphasia Quotien; | — |
Countries
China
Contacts
Public ContactXiaojia Liu
Outcome results
None listed