Schizophrenia
Conditions
Interventions
1:Perphenazine 16-64 mg/d (N=250) or Haloperidol 6-20 mg/d (N=250)
2:Risperidone 2-6mg/d
3:Olanzapine 5-20 mg/d
4:Quetiapine 400-750mg/d
5:Aripiperazole 10~30 mg/d
6:Ziprasidone 80-160 mg/d
Sponsors
The Sixth Hospital / Institute of Mental Health, Peking University
Eligibility
Sex/Gender
All
Age
16 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Both the patients and their parents are Chinese Han descents; 2. The schizophrenia patients at first-onset or the chronic patients with acute and severe symptoms; 3. The total scores of the PANSS are more than 70; 4. All of the subjects give the written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with pregnancy or breast-feeding; 2. Patients with the contraindications of the recommended drugs; 3. Patients with severe or unstable physical diseases; 4. Patients with following heart diseases: QTc>450 ms in male, or QTc>470ms in female; Decompensated and congestive heart failure; Complete left bundle branch block delay.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction rate of PANSS total score; | — |
Countries
China
Contacts
Public ContactDai Zhang
Outcome results
None listed