Effects of flurbiprofen axetil on the incidence of postoperative delirium in elderly orthopedic patients

Effects of flurbiprofen axetil on the incidence of postoperative delirium in elderly orthopedic patients: a prospective, double-blind, randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR-TRC-10000865

Enrollment

Unknown

Registered

2010-05-14

Start date

2010-06-15

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

elderly orthopedic patients

Interventions

Control group:Fat emulsion (placebo) 5ml will be administrated about 15 min before skin incision. After the surgery, Patient controlled intravenous analgesia will be used: Fat emulsion 20ml and sufent

Treatment group:Flurbiprofen axetil 50mg/5ml will be administrated about 15 min before skin incision. After the surgery, Patient controlled intravenous analgesia will be used: flurbiprofen axetil 200m

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Elderly patients (> 60 years); 2. Undergoing elective orthopedic surgery; 3. Preoperative ASA grade<=III; 4. agree to participate in the study.

Exclusion criteria

Exclusion criteria: 1. a preexisting diagnosis of dementia or schizophrenia; 2. severe coagulopathy; 3. severe dysfunction of liver or kidney; 4. with a known allergy to NSAIDs; 5. with a history of peptic ulceration; 6. had received NSAIDs within 24 hours before enrollment.

Design outcomes

Primary

Measure	Time frame
Incidence of Postoperative deliriu;	—

Secondary

Measure	Time frame
Postoperative 30-day mortality;Serum concentrations of IL-6;Postoperative complication;	—

Countries

China

Contacts

Public ContactDongxin Wang

wangdongxin@hotmail.com+86 010 83575138

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026