The effect of antioxidative agents on insulin resistance and the function of pancreatic B cells

Status

Active, not recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR-TRC-10000846

Enrollment

Unknown

Registered

2010-04-26

Start date

2009-11-27

Completion date

Unknown

Last updated

2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obesity

Interventions

Normal FFA group:alpha lipoic acid 600mg+NS 250ml, once a day, 14days

High FFA group:alpha lipoic acid 600mg+NS 250ml, once a day, 14days

Eligibility

Sex/Gender

All

Age

40 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Obese participants to be deviced to groups depends on with high FFA or without high FFA; 2. BMI >=25; 3. high level FFA concentration higher than normal 2 - 3 folders; 4. To be with IR, or B cells been damaged which identified by hyperinsulinemic euglycemic clamp technique.

Exclusion criteria

Exclusion criteria: 1. To be with heart, lung, liver, kidney desfunction; 2. To be with other endocrinology disorders.

Design outcomes

Primary

Measure	Time frame
Malondialdehyde;Interleukin VI;rhTNF;8-iso-PGF2;	—

Secondary

Measure	Time frame
Rate of glucose injection;	—

Countries

China

Contacts

Public ContactHan Ping

hanping85@hotmail.com+86 024 96615-23121

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026