diabetic nephropathy
Conditions
Interventions
control group:basic treatment of western medicine plus placebo
treatment group:basic treatment of western medicine plus Tangshen Formula
Sponsors
China-Japan Friendship hospital
Eligibility
Sex/Gender
All
Age
25 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Consistent with TCM diagnostic criterion of diabetes and syndrome differentiation criterion of Qi and Yin deficiency with blood stasis; 2. Consistent with WHO diagnostic criterion of diabetes: (1) type 2 diabetes; (2) fasting blood glucose level20ug/min; (5) glomerular filtration rate 60-130ml/min; 24 hour urinary protein<2.0g; (6) (4) and/or (5) 3. Systolic blood pressure<140mmHg, diastolic blood pressure<90mmHg, taking or not taking hypotensive drugs; 4. those who have signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Those that do not consistent with the diagnostic criteria of diabetes in TCM; 2. With Fasting blood glucose (FBG) >7.8mmol/L or HbA1c>7.5%; 3. With myocardial infarction history, current vagina pectoris or other vascular event more than once; 4. With recent cardiovascular event; 5. With retinopathy requiring laser treatment; 6. With secondary hypertension; 7. Complicated with cerebrovascular disease, primary kidney disease, other diseases with positive urinary protein, blood disease, enuropathies except for diabetic periphery neuropathy, other endocrine and metabolic disease and mental disorder; 8. Fasting serum TG>10 mmol/L(>886mg/dl) and transaminase elevated over 2 above the upper limit normal; 9. Received drugs such as cortisone, beta-blocker, thiazole diauretics and nicacid within 3 months; 10. Recent infection within 4 weeks; 11. Women in pregnancy or lactation and those who are allergic with the herbal medicine; 12. Those who do not coordinate, i.e. those who do not take dietary management or drugs as ordered; 13. Those who do not fully understand this research procedure or do not consent to participate or those who are with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urinary albumine excretion rate (UAER) and 24-hour; | — |
Secondary
| Measure | Time frame |
|---|---|
| renal function parameters serum creatinine blood urinary nitrogen and estimated glomerular filtration;blood lipid profiler; | — |
Countries
China
Contacts
Public ContactPing Li
Outcome results
None listed