severe head injury
Conditions
Interventions
Group A:RuiSu (enteral nutrition agent ) 30kcal/kg.d, fed via nasogastric tube within 24 to 48 hours after injury
Group B:Ruisu 30Kcal/kg.d and Golden Bifid (synbiotics) 10.5g/d, fed via nasogastric tube within 24 to 48 hours after injury
Sponsors
Third Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Closed severe head injury comfirmed by CT and clinical symptoms; 2. Admission within 24 hours after injury; 3. The score of Glasgow Coma Scale on admission is 5 to 8 and continues more than 12 hours; 4. Aged 18 to 60 years old.
Exclusion criteria
Exclusion criteria: 1. A history of digestive tract, hematological and endocrine diseases; 2. Severe cardiovascular, renal, hepatic and pulmonary dysfuction; 3. Multipal truma; 4. Cancer, pregnancy and malnutrition patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fatality rate;ICU length of hospital stay; | — |
Secondary
| Measure | Time frame |
|---|---|
| Arm muscle circumference,Creatinine height index;IL-4, IL-10, IL-12, IFN-gama;Infectious complications;Biochemical indices of liver function, Complete blood count, Arterial blood gas analysis;PH value of gastric fluid, Analysis of the floroa in gastric fluid;IL-6, CRP; | — |
Countries
China
Contacts
Public ContactMin Tan
Outcome results
None listed