AV block, Heart Failure
Conditions
Interventions
two:The eligible patients undergo the CRT (Insync III 8024 or newer, Medtronic Inc.) procedure, and randomize into biventricular pacing (group A) and right verntricular apical pacing (Group B) after o
Sponsors
First Affiliated Hospital of Nanjing Medical University & Jiangsu Province Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Third degree AV block; 2. Second degree AV-block; 3. Indication for replacement of pacemaker and the ventricular pacing rate more than 40%; 4. LVEF > 35%; 5. NYHA class I-III in previou 90 days; 6. Writtern informed consent from patients or their guardians; 7. Life expectancy >12 months.
Exclusion criteria
Exclusion criteria: 1. Indication for CRT (LVEF <=35%); 2. ACS, PCI and CABG procedures in previou 30 days; 3. Acute myocarditis in last 3 months; 4. Replacement and repair of cardiac valves in previou 6 months; 5. Indications for Replacement and repair of cardiac valves; 6. Implanted prosthetic tricuspid valve; 7. Ongoing or planned pregnancy in the next 6 months; 8. Participation in other clinical trial; 9. Cardiac transplantation; 10. NYHA class IV in previous 90 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The left ventricular ejection fraction (LVEF) and left ventricular end-systolic volume (LVESV); | — |
Secondary
| Measure | Time frame |
|---|---|
| left ventricular end-diastolic volume, LV end-diastolic and endsystolic diameters, Left atrial diment, NYHA class, 6-minute walk distance, the Minnesota Heart Failure Quality of life scoring, N-terminal pro-B-type natriuretic peptide original (NT proBNP) and atrial high-frequency event; | — |
Countries
China
Contacts
Public ContactQijun Shan
Outcome results
None listed