postoperative delirium in critically ill elderly patients
Conditions
Interventions
B:General anesthesia will be induced and maintained during surgery. Patient controlled analgesia will be provided for postoperative analgesia whenever necessary. Sedation level will be assessed with R
Dexmedetomidine group :General anesthesia will be provided during surgery and patient-controlled analgesia will be provided for postoperative analgesia in the same way as those in the placebo group.
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
Male
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elderly patients (age >=65 years); 2. Planning to undergo elective noncardiac surgery under general anesthesia; 3. Admitted to ICU after surgery before 8:00 pm.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate; 2. Preoperative history of schizophrenia, epilepsy, parkinsonism or myasthenia gravis; 3. Inability to communicate in the preoperative period because of coma, profound dementia or language barrier; 4. Brain injury or neurosurgery; 5. Preoperative left ventricular ejection fraction <30%, sick sinus syndrome, severe sinus bradycardia (<50 beats per minute), or second-degree or above atrioventricular block without pacemaker; 6. Severe hepatic dysfunction (Child-Pugh class C); 7. Severe renal dysfunction (requirement of renal replacement therapy before surgery); 8. Those who are unlikely to survive for more than 24 hours after surgery; 9. Other reasons that were considered unsuitable for study participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within the first seven days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative all cause 30-day mortality;Incidence of postoperative non-delirium complications (during hospitalization or until 30 days after surgery);Duration of mechanical ventilation, length of stay in the ICU and hospital after surgery; | — |
Countries
China
Contacts
Public ContactWang Dongxin
Outcome results
None listed