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Combination of Aprepitant and Dexamethasone to Prevent Postoperative Nausea and Vomiting

Combination of Aprepitant and Dexamethasone to Prevent Postoperative Nausea and Vomiting

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-09000739
Enrollment
Unknown
Registered
2009-11-27
Start date
2006-02-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Interventions

Two groups:Aprepitant Immediately before induction of anesthesia Dexamethasone and a combination of Aprepitant and Dexamethasone

Sponsors

None
Lead Sponsor

Eligibility

Sex/Gender
Male
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria: All women (age 18-65 years) undergoing open gynecologic surgery will be eligible

Exclusion criteria

Exclusion criteria: Exclusion criteria: (1) Patients had preexisting nausea or vomiting; (2) Patients had received opioids or drugs with known antiemetic properties in the 24 hours before surgery; (3) Pregnant patients; (4) Patients with history of esophageal reflux, opioid or alcohol abuse.

Design outcomes

Primary

MeasureTime frame
Complete response (no vomiting, no nausea, no rescue antiemetic);—

Secondary

MeasureTime frame
QoR,FLIE questionnaire, Pain and nausea score;—

Countries

China

Contacts

Public ContactMatthew Chan
mtvchan@cuhk.edu.hk+852 26322736

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026