Postmenopausal women with Hypercholesterolemia at risk of Atherosclerosis
Conditions
Interventions
Two groups:Danshen/Gegen (Herbal Medicine) versus placebo, 52 weeks
Sponsors
Department of Medicine & Therapeutics, CUHK
Eligibility
Sex/Gender
Male
Age
45 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: Women aged 45-65 years who had not had menstruation for more than 12 months and with fasting serum LDL >=3.5mmol/L and 4.9 mmol/L will be advised to take statin as recommended by the US guideline, but will be allowed to participate in this trial if they so wish.
Exclusion criteria
Exclusion criteria: Exclusion Criteria: history of diabetes mellitus, hypertension, ischaemic heart disease, cerebrovascular disease, renal impairment, significant drug hypersensitivity, current smoking, hormonal replacement, lipid lowering drugs, blood pressure > 140/90 mmHg on two separate occasions, fasting glucose > 7.0 mmol/L, creatinine 11.3 mmol/L, significant ischaemic ECG changes or angina symptom.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carotid Intima-media thickness at 12 month; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum LDL at 12 Month Serum triglyceride at 12 Month; | — |
Countries
China
Contacts
Public ContactProf. Timothy Kwok (PI)
Outcome results
None listed