Stroke with Moderate to Severe Leukoaraiosis
Conditions
Interventions
Two groups:Daily folate 2mg + Vitamins B6 25mg + B12 500 microgram, 2 year, versus placebo
Sponsors
None listed
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Inclusion Criteria All subjects presenting within 7 months of a stroke or TIA are eligible provided they agree to take study medication, be available for follow-up and provide written informed consent.
Exclusion criteria
Exclusion criteria: Exclusion Criteria Taking vitamins on medical advice Independent self-medication with vitamin supplements containing B6, B12 or folate Taking methotrexate for any reason Pregnancy or women of child bearing potential who are at risk of pregnancy Limited (less than two years) life expectancy Auditory, visual, or language impairment, severe enough to prevent cognitive assessment Pacemaker or other contraindication to MRI scanning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Stroke (ischemic or hemorrhagic), myocardial infarction or death from any vascular cause; | — |
Secondary
| Measure | Time frame |
|---|---|
| Transient ischemic attack, depression, dementia, unstable angina, revascularization procedures of the coronary, cerebral or peripheral circulations; | — |
Countries
China
Contacts
Public ContactVincent Chung Tong MOK
Outcome results
None listed