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Comparative pharmacokinetics after thoracic paravertebral administration of levobupivacaine with or without epinephrine

Comparative pharmacokinetics after thoracic paravertebral administration of levobupivacaine with or without epinephrine

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR-TRC-09000685
Enrollment
Unknown
Registered
2006-04-12
Start date
2002-08-01
Completion date
Unknown
Last updated
2017-04-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

nil

Interventions

Two groups:Plain levobupivacaine or levobupivacaine with epinephrine Plain levobupivacaine or levobupivacaine with epinephrine versus Levobupivacaine or Levobupivacaine with epinephrine

Sponsors

Dept of Anaesthesia and Inteneive Care, CUHK
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: Inclusion: All consenting adult ASA (American Society of Anaesthesiologists) class 1-3 patients under the age of 75 years who are due to receive a thoracic paravertebral block as part of their routine perioperative management will be recruited for this study.

Exclusion criteria

Exclusion criteria: Exclusion: The following patients will be excluded from the study: 1. Patients with a known allergy to local anaesthetic drugs. 2. Patient with infection at the site of block placement. 3. Patient with a bleeding tendency or evidence of coagulopathy. 4. Patient with pre-existing neurological or muscular disorders. 5. Patients with deranged liver or renal function.

Design outcomes

Primary

MeasureTime frame
Pharmacokinetics variable Cpmax;

Secondary

MeasureTime frame
Tmax, Vd, Cl, T1/2 and MBRT over 24 hour;

Countries

China

Contacts

Public ContactManoj K Karmakar
karmakar@cuhk.u.hk+852 26321311

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026