Coronary Heart Disease & Chronic Renal Insufficiency
Conditions
Interventions
Two groups:Theophylline infusion in addition to N-acetylcysteine and saline hydration once versus No drug in addition to N-acetylcysteine and saline hydration
Sponsors
Division of Cardiology, Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion: 1. Patient willing to sign informed consent form; 2. Patient over 18 years of age; 3. Patient undergoing coronary angiography or intervention; 4. Patient with a serum creatinine 1.30 to 4.52 mg/dL (115 to 400 umol/l).
Exclusion criteria
Exclusion criteria: Exclusion: 1. Patient with known allergy to or have already taken N-acetylcysteine (Fluimucil), theophylline or contrast agents; 2. Patinet is in acute renal failure (2 Cr level differ by 15% within 1 month); 3. Patient in cardiogenic shock; 4. Patient with significant cardiac arrhythmia; 5. Pregnant women; 6. Patients with child bearing age without appropriate contraception; 7. Current dialysis patient; 8. Concomitant use of dopamine and mannitol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development of contrast nephropathy, defined as an increase in serum creatinine concentration of > and = 0.5 mg/dL, or a reduction in estimated glomerular filtration rate of > and = 25% of the baseline value, within 48 hours after the procedure; | — |
Countries
China
Contacts
Public ContactJeffrey Wing Hong FUNG
Outcome results
None listed