Heart and Blood Vessel Diseases
Conditions
Interventions
Two groups:24 weels haemodialysis with high-flux dialyzer versis 24 weeks haemodialysis with low-flux dialyzer
Sponsors
CUHK
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Anuric (urine output < 100 ml/day); 2. Age between 18 and 75 years old; 3. On hemodialysis treatment with bicarbonate dialysate, for at least 3 months; 4. On a dialyzer reuse program using polysulfone dialyzer for at least 3 months; 5. Stable with no change in dialysis prescription for at least 3 months preceding enrolment; 6. Vascular access functioning properly; 7. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Contraindication for dialyzer reuse; 2. Active infection, inflammatory disease, ongoing malignancy or active phase immune disease; 3. Patient with immunosuppressive medication; 4. Recently measured C-reactive protein level > 50 mg/L; 5. Predictable survival < 1 year; 6. Planned renal transplantation within the 1-year study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparing the arterial pulse wave velocity and the inflammatory indices between the 2 groups.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparing the biochemical markers between the 2 groups.; | — |
Countries
China
Contacts
Public ContactCheng Yuk Lun
Outcome results
None listed