Heart and Blood Vessel Diseases
Conditions
Interventions
Two groups:Ramipril + Diuretics vs. Irbesartan +Diuretics vs. Diuretics alone
Sponsors
Department of Medicine & Therapeutics, The Chinese University of Hong Kong
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion: 1. Signed informed consent; 2. Age >18 yrs; 3. history of heart failure for 2 months prio to screening; 4. NYHA Functional Class II-IV; 5. LV EF >45% by ECHO or a radionucleotide technique; 6. Therapy with diuretics with stable dose >14 days prior to screening.
Exclusion criteria
Exclusion criteria: Exclusion: 1. NHYA class I; 2. Inability to answer the QOL questionnaire; 3. Myocardial infarction within 3 months; 4. unstable angina within 1 month; 5. Significant cardiac valvular heart disease; 6. Hypotension SBP 105 ors SBP> 200 mmHg); 8. uncontrolled serious cardiac arrhythmias associated with a ventricular rate >100 bpm at study entry; 9. concurrent therapy with CCB, Betablocker, ACEI, AII or positive inotropic agents other than digoxin for control of AF
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Number of hospital admissions for heart failure or mortality;2. Quality of life assessed by the Minnesota Quality of life Questionnaire;3. In ambulatory patients the exercise duration assesssed by 6 min corridor walk test; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of side-effects, effect on levels of natriuretic peptides, effect on doppler-echocardiographic derived measurements of left ventricular diastolic function.; | — |
Countries
China
Contacts
Public ContactProf. John E. Sanderson
Outcome results
None listed